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Research results provide clinical briefing on the effects of supplements on AMD.

November 2017

John NolanCurrently incurable and largely untreatable, AMD affects more than 600,000 people in the UK and is increasingly common in those aged over 60. Another 200 are diagnosed every day and the number of those affected nationwide is set to more than double by 2050.

During the trial, conducted by a team from the Nutrition Research Centre Ireland (NRCI), the volunteers taking part received supplementary meso-zeaxanthin, zeaxanthin and lutein, the three carotenoids that make up macular pigment, plus co-nutrients (vitamin C, vitamin E, zinc, and copper). Carotenoids are naturally-occurring pigments that give many fruit and vegetables their colour.

Those living with AMD would usually have been expected to experience a continued deterioration in their vision over the two years of the clinical trial. Instead, those receiving carotenoids showed a significant improvement across 24 out of 32 tests of vision.

 

Most patients showed an improvement in their sight, with 40% of trial participants displaying what is deemed to be a clinically meaningful improvement in their vision after 24 months. Improvements in vision were particularly marked among those receiving all three carotenoids, including meso-zeaxanthin, compared to those receiving only zeaxanthin and lutein.

The trial – called CREST (Central Retinal Enrichment Supplementation Trial) AMD – was conducted at Waterford Institute of Technology (WIT) by KwadwoOwusu Akuffo; Stephen Beatty; Jim Stack; David Kelly; Laura Corcoran and John Nolan from NRCI along with Irene Leung, University College London Institute of Ophthalmology, Tunde Peto, Queen’s University Belfast; and Jim Stringham, University of Georgia, USA. Results from the study are published in Investigative Ophthalmology & Visual Science (IOVS), the most respected, peer-reviewed journal in eye science.

Prof John Nolan who co-founded the NRCI and the original Macular Pigment Research Group in Waterford and who is now Howard Chair of Human Nutrition at WIT, said: “These are hugely exciting findings and build on previous work that has been done at our Centre and elsewhere. AMD and the impaired vision that comes with it are a huge burden for patients and their families. The disease also brings a considerable economic burden, especially in its later stages – it currently costs the NHS an estimated £1.6 billion. So, there’s a huge prize in finding an early intervention that can avert the need for expensive therapies and supports.

“These findings are the culmination of a tremendous body of work by a diverse group of committed people going back over several years while we also owe a huge debt of gratitude to the volunteers who participated in the trials without any guarantee of a favourable outcome. It’s been both humbling and rewarding to work with these people and to see the difference in their quality-of-life as the decline in their vision is arrested and they begin to notice a distinct improvement.

“The team involved also appreciate the support we have consistently received from Waterford Institute of Technology, and the Howard Foundation, UK, and a range of funding agencies including the prestigious European Research Council (ERC) who funded this project in 2011.”

Learn more about Nutrition Research Centre Ireland here or visit and read Investigative Ophthalmology & Visual Science.

 
 
 
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